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If you suffer from joint discomfort, DONA® Crystalline Glucosamine Sulfate can help.

DONA® is the original Crystalline Glucosamine Sulfate that has been proven effective in major clinical trials. Improving joint flexibility and overall joint health, DONA® works by helping to maintain and stabilize the cartilage between the joints. Healthy cartilage keeps your joints flexible, allowing you to return to the activities you love, such as walking, climbing stairs, swimming, running, and even the simple joy of picking up your grandchild!

  • Promotes healthy cartilage*
  • Lubricates joints*
  • Supports joint mobility and flexibility*
  • Physician Recommended*
  • Available without a prescription*

Glucosamine Sulfate Proven Effective

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Results of the first 3-year study were published in 2001 in The Lancet, a prestigious, international medical journal, and showed Glucosamine Sulfate to be effective in improving and maintaining joint flexibility and cartilage health 1 – click here for full study.

In 2002, a second 3-year study was published in the JAMA's Archives of Internal Medicine confirming previous findings and suggesting that Glucosamine Sulfate could be used to help maintain and stabilize joint function and cartilage 2 – click here for full study.

An 8-year observational study was later conducted on patients taking glucosamine sulfate for 3 years and 5 years off. It found that Glucosamine Sulfate not only was beneficial for joint health but it decreases the chance of total knee replacement by 73% 3 - click here for full study.

In a 6-month controlled clinical trial called the GUIDE Trail, it showed that Glucosamine Sulfate’s efficacy on knee osteoarthritis symptoms was significantly better on all parameters as compared to placebo and acetaminophen 4 - click here for full study.

Beware of Imitations – Not all Glucosamines are the same!

Glucosamine Sulfate has 150 pre-clinical and clinical studies with 12,125 subjects and 91 leading institutions. Leading medical journals like The Lancet and JAMA's Archives of Internal Medicine caution that without head-to-head trials, other glucosamine products, like Glucosamine hydrochloride (HCI), may not provide the same benefits as Glucosamine Sulfate. So beware of imitations.*


Customers and healthcare providers may be confused as to which product they should purchase or recommend. Many believe that all glucosamines are the same and that it doesn’t matter which product you choose or which glucosamine (Sulfate or Hydrochloride) you should take. However, the GAIT study – one of the largest U.S. studies done on Glucosamine and Chondroitin– found that patients who took glucosamine (hydrochloride) and chondroitin sulfate alone or in combination, had outcomes similar to those experienced by patients who took celecoxib or placebo (sugar) pills. This new information was incorrectly used by some people as evidence that glucosamine and chondroitin as ingredients do not work for joint health. What is accurate, in fact, is that in studies that occurred before the GAIT trials it was only glucosamine hydrochloride that had questionable efficacy. In its editorial after the GAIT findings were announced, The New England Journal of Medicine stated the following – click here for full editorial:

If patients, choose to take dietary supplements to control their symptoms, they should be advised to take glucosamine sulfate rather than glucosamine hydrochloride and, for those with severe pain, that taking chondroitin sulfate with glucosamine sulfate may have an additive effect. 5


Frequently Asked Questions

How does DONA work?

As we age, or if we place a lot of constant stress on our joints, the cartilage begins to break down and wear thinner. Athletes or dancers often show signs of cartilage wear at a much younger age. DONA works by helping to maintain the cartilage in the joints from breaking down. Healthy cartilage keeps your joint flexible and free of any discomfort and that makes just about everything you do feel easier.

How safe is DONA?

Studies show that DONA is as safe as a sugar pill (placebo).

How long should I take DONA for?

Although you may feel some relief from joint stiffness in as little as two weeks, you won't actually be getting the full benefit of DONA before 3 months. Because DONA helps you maintain and stabilize the cartilage, it can continue working for you as long as you take it.

Real Customer Reviews

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Keeps me from crying.

Keeps me from crying when I walk up stairs. True story, and I live on the 2nd floor. My doctor recommended Dona because they actually put in as much glucosamine as they say they do. A lot of brands don't, I've tried a few others and they were worthless. If it wasn't for Dona I wouldn't have been able to move in with my husband because of the stairs.

- Cathy, Verified DONA Customer
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First time I have seen a difference using glucsominer!!

I have just finished my first box of DONA and I can really FEEL the difference. I have osteoarthritis and I have had injections, pills, and there was no change in my condition! Since I have been taking DONA, I have much more mobility and less stiffness after only two weeks. So, I am sold on it, so far. I am very optimistic about using my second box. I really have faith in this product! Everyone should try it! I think you will be amazed as I was. And this is only the start!

- Linda, Verified DONA Customer
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Love this product!!

I have used this stuff for years! I recommend it to everyone I know. If for some reason I am without it for a couple of days I can really tell the difference in my joints. I have RA and this was recommended to me by a Rheumatoligst. It is the best recommendation I ever received from a doctor.

- Anonymous, Verified DONA Customer
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Directions for Use


Take two caplets together daily with water or juice.


Due to its mechanism of action, the product may take 1-2 weeks, or possibly longer, to notice any effects. Optimal effects on joint mobility have been observed after 12 weeks of daily administration. 

Store in a cool, dry place.

Keep out of the reach of children.

As with any nutritional product, please consult your physician before taking. It you are pregnant or breast feeding, ask you Doctor before taking.

Use only as directed. Results May Vary.

Other information:

Glucosamine is derived from shellfish; if you are allergic to shellfish, please consult your doctor before taking.
DONA® contains the original Crystalline Glucosamine Sulfate discovered and patented by Rotta Research Laboratorium, sold in more than 60 countries around the world as a prescription drug.

Taking DONA® with or without food is up to the customer. We simply ask that customers be consistent.

Taking DONA® in the morning or at night is up to the customer. We simply ask that customers be consistent.

DONA® is a pure and chemically well characterized compound.

DONA® is manufactured in accordance with Good Manufacturing Practices.


The recommended daily dose is 1500 mg taken once-a-day - which is equal to 2 DONA caplets once-a-day. Caplets are available in bottles, with the caplets loose in a bottle.

Supplement Facts

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Looking to download our latest brochure? Go To Our Media Page
  1. The Lancet. Vol 357, January, 2001;
  2. Arch Intern Med. Vol 162, Oct 14, 2002;
  3. Arthritis Rheum. 2004; 50, 9 (suppl); 251;
  4. Arthritis and Rheumatism 2005: 52,, 9 (suppl): 1203 GUIDE;
  5. N. Engl J Med 354;8 Nutritional Supplements for Knee Osteoarthritis – Still No Resulution.